Excellence to the CO-RE Introducing the CO-RE ® II Technology
Contents
Introduction ....................................................................................... 3 Benefits . ............................................................................................ 3 Timeline . ............................................................................................ 3 Cost .................................................................................................... 4 Detailed Description of the CO-RE II ® Technology ...................... 4 Pipette Tips Stop Disk Compatibility Labeling Verification ......................................................................................... 6 Risk Management ............................................................................ 6 Affected Environment ...................................................................... 6 Pipette Tips Stop Disk Instrument Firmware and Software Teaching Needles CO-RE Paddles Service Specifics .............................................................................. 8 Microlab STAR/Microlab VANTAGE Service Software Microlab NIMBUS Toolbox Universal Channel Calibration Tool Microlab NIMBUS 4-Probe Channel Calibration Tool 96 Multi Probe Head Tools FAQ . ................................................................................................. 10
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Introduction
g Up to 15x Life Span g Less Wear and Tear g Higher Precision Pipette Tip Alignment g Simplified Serviceability and Reduced Preventative Maintenance
Hamilton is introducing CO-RE ® II technology to the existing automated liquid handling product portfolio.
CO-RE II technology consists of two parts: 1. Consumables: pipette tips 2. Hardware: stop disks The introduction of the CO-RE II technology will be rolled out in two phases: 1. Phase 1: Introduction of CO-RE II tips 2. Phase 2: Introduction of CO-RE II stop disks With this Customer Information , Hamilton is informing customers about the upcoming switch from the current CO-RE to CO-RE II consumables and the availability of CO-RE II tips. The actual introduction of the CO-RE II parts will be announced upon the availability of all necessary Test and Validation Reports through the official change process. BENEFITS OF THE NEW TECHNOLOGY The new CO-RE II tip design, in combination with the new stop disk, will offer numerous benefits.
Improved tip retention
g
g Extended service interval requirements g Equivalent fluidic performance on existing methods with no change in TADM or liquid class g Reduced service costs
TIMELINE OF UPCOMING STEPS Pipette Tip Launch
All existing catalog case part numbers for 10 µL, 50 µL, 300 µL, 1000 µL, slim, piercing, and wide bore tips for use with 1000 µL pipetting channels will be revised to CO-RE II in January 2022: There will be a transition phase. Once all current CO-RE tips have been consumed, we will begin delivering only CO-RE II tips. Hardware Launch All Hamilton liquid handling platforms will be produced with CO-RE II 1000 µL pipetting channels and 96 MPH, starting in July 2022. This includes the following products:
g Extended tip sealing life of o-rings up to 15x the average life span g Lifetime stop-disk design g Enhanced hardware chemical resistance g Improved tip alignment
Microlab PREP Microlab NIMBUS
g
g
Microlab STAR
g
Microlab VANTAGE
g
ZEUS
g
INTENDED TIMELINE
Hardware Launch July 2022
Introduction to CO-RE II Technology 09/30/2021
Pipette Tip Launch January 2022
Aug I Sept I Oct I Nov I Dec I Jan I Feb I Mar I Apr I May I Jun I Jul I Aug I Sept I Oct I Nov I Dec
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Current CO-RE Tips
CO-RE II Tips
CO-RE Stop Disk CO-RE II Stop Disk
Firmware Update Optional
Firmware Update Optional Firmware Update Mandatory
Not Compatible
COST There will be no price changes between current CO-RE and CO-RE II consumables. There is no cost increase when purchasing a new instrument equipped with CO-RE II.
COMPATIBILITY The compatibility of the current CO-RE and the CO-RE II technology is as follows:
Current CO-RE Tips CO-RE II Tips
Current CO-RE stop disk
a
a
DETAILED DESCRIPTION OF THE CO-RE II TECHNOLOGY Pipette Tips
CO-RE II stop disk
a
r
Table 1: Compatibility Matrix of current CO-RE and CO-RE II technology.
All CO-RE II tips include a new sealing surface to interface with the CO-RE II stop disk. Geometry that interfaces with the current CO-RE stop disk is identical between the two tip designs and performance remains unaffected. Stop Disk Current CO-RE stop disks compress an o-ring to retain the tip to the pipetting channel and to create a seal. CO-RE II stop disks decouple sealing and tip retention functionality to improve longevity and durability of the o-ring and stop disk assembly.
Part
Material
Spacer
6-4 ELI Titanium
Housing
6-4 ELI Titanium
Drive Ring
6-4 ELI Titanium
Steel Ball Bearing
316 Stainless Steel
O-Ring
Silicone
Table 2: Materials used in CO-RE II.
The CO-RE II stop disk will be used on 1 mL independent channels and 96 MPH.
Current CO-RE Stop Disk
CO-RE II Stop Disk
Metal Coupler instead of CO-RE o-ring
New CO-RE II sealing surface
Current CO-RE Tip
CO-RE II Tip
Figure 1: Difference between current CO-RE and CO-RE II Tips.
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Aug I Sept I Oct I Nov I Dec I Jan I Feb I Mar I Apr I May I Jun I Jul I Aug I Sept I Oc
Hardware Launch July 2022
Introduction to CO-RE II Technology 09/30/2021
Pipette Tip Launch January 2022
Aug I Sept I Oct I Nov I Dec I Jan I Feb I Mar I Apr I May I Jun I Jul I Aug I Sept I Oct
LABELING Tip Part Numbers Current CO-RE catalog tip and instrument part numbers will transition to CO-RE II on the launch date. Example: Part Material Spacer 6-4 ELI Titanium Current CO-RE Tips CO-RE II Tips CO-RE Stop Disk Firmware Update Optional Firmware Update Optional CO-RE II Stop Disk Not Compatible Firmware Update Mandatory
Current CO-RE Stop Disk CO-RE II Stop Disk
Housing
6-4 ELI Titanium 6-4 ELI Titanium Part Number CO-RE II Tips
Current CO-RE Tips Part Number Current CO-RE Tip
CO-RE II Tips
Description
C
Existing 4-Probe CCT New 4-Probe CCT Universal CCT CO-RE Stop Disk CO-RE II Stop Disk 235905
Drive Ring
Firmware Update Optional
Firmware Update Optional Firmware Update Mandatory
CO-RE Stop Disk CO-RE II Stop Disk
8 x 480 Conductive Tips (1000 µL), Filt red
235905
Steel Ball Bearing
316 Stainless Steel
Not Compatible
O-Ring
Silicone
Part
Material
Table 3: CO-RE II tip part numbers.
Spacer
6-4 ELI Titanium 6-4 ELI Titanium 6-4 ELI Titanium 316 Stainless Steel
Tip Rack Label Tip rack labels will include C2 indicating CO-RE II designation in human readable text. The tip rack barcode will not change. Example: Part Number CO-RE Tip Description Part Number CO-RE II Tips 235905 8 x 480 Conductive Tips (1000 µL),Filtered 235905 Housing Drive Ring Steel Ball Bearing O-Ring Current CO-RE Stop Disk CO-RE II Stop Disk Existing 4-Probe CCT New 4-Probe CCT Universal CCT
Curre
CO-RE Stop Disk CO-RE II Stop Disk
Silicone
Current CO-RE Rack Label Part Number CO-RE Tip Description
CO-RE II Rack Label
Part Number CO-RE II Tips
235905
8 x 480 Conductive Tips (1000 µL),Filtered 235905
Figure 2: CO-RE II rack label example. Current CO-RE ack Label
CO-RE II Rack Label
Current CO-RE Tip Blister Label (Exerpt)
CO-RE II Tip Blister Label (Exerpt)
Blister and Case Label Blister and case labels will indicate CO-RE II with new artwork. Example:
Current CO-RE Tip Blister Label (Exerpt)
CO-RE II Tip Blister Label (Exerpt)
Current CO-RE Tip Box Label (Exerpt)
CO-RE II Tip Box Label (Exerpt)
Current CO-RE Tip Box Label (Exerpt)
CO-RE II Tip Box Label (Exerpt)
CO-RE II Sample PN
Description
235966 Rev. 45 235948 Rev. 45
50 uL,cond,NF,FTR 50 uL,cond,F,FTR 50 uL,cond,NF,NTR 300 uL,cond,NF,FTR 300 uL,cond,F,FTR 300 uL,cond,NF,NTR 50 uL,cond,F,FTR 1000 uL,cond,NF,FTR 1000 uL,cond,F,FTR 300 uL,cond,NF,FTR Slim,cond,NF,FTR Slim,cond,F,FTR 300 uL,cond,NF,NTR Piercing,cond,NF,FTR,S Piercing,cond,F,FTR,S 1000 uL,cond,F,FTR 300 uL,cond,F,FTR 1000 uL,cond,NF,FTR Description 50 uL,cond,NF,FTR 50 uL,cond,NF,NTR
235947 Rev. 45 235902 Rev. 45 CO-RE II Sample PN 235903 Rev. 45 235950 Rev. 45 235948 Rev. 45 235904 Rev. 45 235905 Rev. 45 235902 Rev. 45 235806 Rev. 45 235647 Rev. 45 235950 Rev. 45 235659 Rev. 45 235649 Rev. 45 235905 Rev. 45 235904 Rev. 45 235806 Rev. 45 235647 Rev. 45 235659 Rev. 45 235649 Rev. 45 235966 Rev. 45 235947 Rev. 45 235903 Rev. 45
Figure 3: CO-RE II blister and case label examples.
Slim,cond,NF,FTR Slim,cond,F,FTR
5
Piercing,cond,NF,FTR,S Piercing,cond,F,FTR,S
VERIFICATION Hamilton has performed extensive testing of the new CO-RE II tips, stop disks, and supporting environment. Testing has confirmed that CO-RE II tips perform equivalently to current CO-RE tips when used on a current CO-RE stop disk without changes to firmware, software, liquid classes, etc. The main aspects of verification testing included the following:
AFFECTED ENVIRONMENT Pipette Tips
The new tips will be featured with a slightly different geometry to accommodate the new o-ring real. Stop Disk The CO-RE II stop disk is a modified design which separates the function of retaining the tip and sealing the channel against the environment. Instrument Firmware and Software Changes to firmware, software, methods, and liquid classes are not required to switch from current CO-RE to CO-RE II tips. CO-RE II stop disks do not require changes to methods or liquid classes. All adjustments required to use CO-RE II stop disks are built into the new CO-RE II firmware.
Gravimetric Performance
g
TADM Performance
g
g Capacitive Liquid Level Detection (cLLD) g Filter Performance g Tip Pickup and Reliability g Chemical Compatibility g Lifetime Testing RISK MANAGEMENT Hamilton has assessed the risk of transitioning to CO-RE II tips and stop disks in detail. The following steps have been performed in order to mitigate risk:
Current CO-RE Tips
CO-RE II Tips Firmware Update Optional
Current CO-RE stop disk CO-RE II stop disk
Firmware Update Optional
Performance testing of CO-RE II tips with current CO-RE stop disks (backwards-compatibility) Testing of CO-RE II stop disks
g
Not Compatible
Firmware Update Mandatory
g
g Testing of supporting firmware, software, and hardware environment g Dedicated engineering and service resources will be available to support the transition g Maintaining the capability to produce current CO-RE tips at launch, but will be fully transitioning to CO-RE II production
Table 4: Firmware compatibilities.
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Teaching Needles The CO-RE II teaching needles are backwards-compatible with current CO-RE stop disks, and the geometry that interfaces with the current CO-RE stop disk is identical. If you upgrade to the CO-RE II stop disk, the new CO-RE II teaching needles are required to accommodate the change in geometry of the CO-RE II stop disk. These new teaching needles will be available in ample time before the stop disk change is executed. CO-RE II teaching needles include an external groove for the easy identification of CO-RE II compatibility.
Current CO-RE Stop Disk
CO-RE II Stop Disk
Sealing Surface ID Groove
Current Teaching Needle
CO-RE II Teaching Needle
Figure 4: Difference between current CO-RE and CO-RE II teaching needle.
CO-RE Paddles The CO-RE II paddles are backwards-compatible with current CO-RE stop disks, and the geometry that interfaces with the current CO-RE stop disk is identical. If you upgrade to the CO-RE II stop disk, the new CO-RE II paddles are required to accommodate the change in geometry of the CO-RE II stop disk. These new paddles will be available in ample time before the stop disk change is executed. CO-RE II paddles include an external groove for the easy identification of CO-RE II compatibility.
Current CO-RE Stop Disk
CO-RE II Stop Disk
Current CO-RE Paddle
CO-RE II Paddle
Figure 5: Difference between current CO-RE and CO-RE II paddles.
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SERVICE SPECIFICS MICROLAB STAR/MICROLAB VANTAGE Service Software No changes to service software are required to switch from the current CO-RE to CO-RE II tips. CO-RE II stop disks require new service software and a new channel calibration tool (CCT) for use on the Microlab STAR and Microlab VANTAGE. The new service software will be simplified to improve ease of use and execution times. Details regarding the new service software will be announced through the official change process.
MICROLAB NIMBUS Toolbox No changes to the Microlab NIMBUS toolbox or service software are required to switch from the current CO-RE to CO-RE II tips. CO-RE II stop disks require a new Microlab NIMBUS toolbox and new channel calibration tool (CCT) for use on the Microlab NIMBUS. The new MICROLAB NIMBUS toolbox will be compatible with the following hardware combinations:
Current CO-RE Stop Disk
CO-RE II Stop Disk
a
r
Existing 4-Probe CCT
a
a
New 4-Probe CCT
a
a
Universal CCT
Table 5: Compatibility Matrix for MICROLAB NIMBUS toolbox.
Details regarding the new MICROLAB NIMBUS toolbox will be announced through the official change process.
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Universal Channel Calibration Tool (CCT II) A new Channel Calibration Tool is required to
accommodate the change to the CO-RE II stop disk. New service software and macros are required for use with the new CCT. The new tool is backwards-compatible and can be used for current CO-RE or CO-RE II stop disks. It can also be used universally on Hamilton robotic platforms, including the Microlab STAR line, Microlab VANTAGE, and Microlab NIMBUS. Details regarding the use of the new Universal Channel Calibration Tool will be announced through the official change process.
Figure 6: Universal Channel Calibration Tool.
MICROLAB NIMBUS 4-Probe Channel Calibration Tool (CCT II)
A new NIMBUS 4-Probe Channel Calibration Tool II is required to accommodate the change to the CO-RE II stop disk. Alternatively, the Universal Channel Calibration Tool may be used on the Microlab NIMBUS with current CO-RE or CO-RE II stop disks. Both configurations require the use of the new Microlab NIMBUS service software. The new 4-Probe tool is backwards-compatible and can be used for current CO-RE or CO-RE II stop disks. Details
regarding the use of the new 4-Probe Channel Calibration Tool will be announced through the official change process.
Figure 7: MICROLAB NIMBUS 4-Probe Channel Calibration Tool.
96 Multi Probe Head Tools New alignment and adjustment tools are required to accommodate the change to the CO-RE II 96 MPH. The new tools are backwards-compatible and can be used for current CO-RE or CO-RE II equipped 96 MPH. Details regarding the use of the new 96 MPH alignment and adjustment tools will be announced through the official change process.
Figure 8: 96 MPH Adjustment Tool.
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CO-RE II FAQ’S
TIMING AND INFORMATION 1. What is the official date for the consumables launch? Tentative Date: January 2022 2. Will current CO-RE tips continue to be available following this launch? Upon release of the CO-RE II consumables, there will be a transition phase. Once all current CO-RE stock has been consumed, only CO-RE II tips will be available. 3. What Is the official date for the hardware launch? Tentative Date: July 2022 4. Will wide bore and specialty tips also be produced as CO-RE II? Yes, all CO-RE tips which are be used with the stop disk of 1 mL Channel and 96 MPH (standard tips, wide bore, slim, piercing). 5. Do the CO-RE II tips have a new part number? No, the part number will not change. 6. Will there be a new revision number for CO-RE II tips? Yes. Hamilton Company revisions will be updated to Revision K, and Hamilton AG revisions will be updated to Revision 50. COMPATIBILITY 7. Is there an error which appears if I use current CO-RE tip with CO-RE II stop disk? No. The current CO-RE tip paired with the CO-RE II stop disk may leak. CO-RE II TIP SAMPLES 8. What is the availability expectation for samples of CO-RE II tips?
9. Which tip samples will be available?
CO-RE II Sample P/N Description 235966
50 µL, cond, NF, FTR
235948
50 µL, cond, F, FTR
235947
50 µL, cond, NF, NTR
235902
300 µL, cond, NF, FTR
235903
300 µL, cond, F, FTR
235950
300 µL, cond, NF, NTR
235904
1000 µL, cond, NF, FTR
235905
1000 µL, cond, F, FTR
235806
Slim, cond, NF, FTR
235647
Slim, cond, F, FTR
CO-RE II STOP DISK SAMPLES 10. What is the availability expectation for early access to CO-RE II hardware? Spring 2022. SOFTWARE/FIRMWARE 11. Will there be any changes to the firmware? No changes for CO-RE II tips. CO-RE II hardware requires updated channel firmware only. 12. What is the timing of the communication of details around these changes? Tentative date: Spring 2022. 13. Is the new Service Software backwards compatible? Yes.
CO-RE II tips will be available in October 2021 with sample-specific tip revision numbers.
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VERIFICATION 14. What verification testing will be available to show evidence of CO-RE II pipetting performance? A test summary document demonstrating backwards compatibility of CO-RE II tips with a current CO-RE stop disk will be available for distribution in October 2021, and a test summary document for CO-RE II stop disks and the affected environment will be available for distribution Spring 2022. MANAGEMENT OF RISK DURING TRANSITION? 15. What is Hamilton’s backup strategy in the event of production startup issues with CO-RE II consumables? Hamilton has extensively tested CO-RE II tips to mitigate the risk of startup issues. Hamilton is also capable of producing both current CO-RE and CO-RE II consumables in the short term. SPECIFICATION 16. Will racks, barcodes, and tip numbers change? Racks, barcodes, and tip part numbers will not change, other than addition of a C2 designation in human readable text. Blister and case labels will change. SERVICING 17. Will there be updated service instructions and manuals for CO-RE II? Service instructions and manuals for CO-RE II will be updated upon hardware release. 18. What is the replacement interval for CO-RE II hardware?
Replacement of CO-RE II stop disks is not foreseen due to improved life span. The replacement interval for CO-RE II o-rings is TBD. 19. Is the replacement activity expected to be a service event, or can it be done by the lab user? O-Rings can be replaced by the lab user. Instructions will be provided prior to CO-RE II hardware launch. Periodic calibration and verification must still be performed as part of a service event. 20. Is there more information on the use of a torque tool for use in installation? CO-RE II stop disks include a 2 mm hex on the distal end to aid in installation. The installation torque for a CO-RE II stop disk is 15 cNm. ADDITIONAL QUESTIONS 21. Is the tip rack recognition with CO-RE II improved/changed? No. The barcode will only have a C2 designation in human readable text indication. 22. Still have questions? Reach out to the Hamilton CO-RE II team at CO-REII@hamiltoncompany.com.
©2021 Hamilton Company. All rights reserved. All other trademarks are owned and/or registered by Hamilton Company in the U.S. and/or other countries. BR-2109-14 V1.0— 09/2021
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