Introducing the CO-RE®-II Technology

Introduction

g Up to 15x Life Span g Less Wear and Tear g Higher Precision Pipette Tip Alignment g Simplified Serviceability and Reduced Preventative Maintenance

Hamilton is introducing CO-RE ® II technology to the existing automated liquid handling product portfolio.

CO-RE II technology consists of two parts: 1. Consumables: pipette tips 2. Hardware: stop disks The introduction of the CO-RE II technology will be rolled out in two phases: 1. Phase 1: Introduction of CO-RE II tips 2. Phase 2: Introduction of CO-RE II stop disks With this Customer Information , Hamilton is informing customers about the upcoming switch from the current CO-RE to CO-RE II consumables and the availability of CO-RE II tips. The actual introduction of the CO-RE II parts will be announced upon the availability of all necessary Test and Validation Reports through the official change process. BENEFITS OF THE NEW TECHNOLOGY The new CO-RE II tip design, in combination with the new stop disk, will offer numerous benefits.

Improved tip retention

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g Extended service interval requirements g Equivalent fluidic performance on existing methods with no change in TADM or liquid class g Reduced service costs

TIMELINE OF UPCOMING STEPS Pipette Tip Launch

All existing catalog case part numbers for 10 µL, 50 µL, 300 µL, 1000 µL, slim, piercing, and wide bore tips for use with 1000 µL pipetting channels will be revised to CO-RE II in January 2022: There will be a transition phase. Once all current CO-RE tips have been consumed, we will begin delivering only CO-RE II tips. Hardware Launch All Hamilton liquid handling platforms will be produced with CO-RE II 1000 µL pipetting channels and 96 MPH, starting in July 2022. This includes the following products:

g Extended tip sealing life of o-rings up to 15x the average life span g Lifetime stop-disk design g Enhanced hardware chemical resistance g Improved tip alignment

Microlab PREP Microlab NIMBUS

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Microlab STAR

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Microlab VANTAGE

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ZEUS

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INTENDED TIMELINE

Hardware Launch July 2022

Introduction to CO-RE II Technology 09/30/2021

Pipette Tip Launch January 2022

Aug I Sept I Oct I Nov I Dec I Jan I Feb I Mar I Apr I May I Jun I Jul I Aug I Sept I Oct I Nov I Dec

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Current CO-RE Tips

CO-RE II Tips

CO-RE Stop Disk CO-RE II Stop Disk

Firmware Update Optional

Firmware Update Optional Firmware Update Mandatory

Not Compatible

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