VERIFICATION Hamilton has performed extensive testing of the new CO-RE II tips, stop disks, and supporting environment. Testing has confirmed that CO-RE II tips perform equivalently to current CO-RE tips when used on a current CO-RE stop disk without changes to firmware, software, liquid classes, etc. The main aspects of verification testing included the following:
AFFECTED ENVIRONMENT Pipette Tips
The new tips will be featured with a slightly different geometry to accommodate the new o-ring real. Stop Disk The CO-RE II stop disk is a modified design which separates the function of retaining the tip and sealing the channel against the environment. Instrument Firmware and Software Changes to firmware, software, methods, and liquid classes are not required to switch from current CO-RE to CO-RE II tips. CO-RE II stop disks do not require changes to methods or liquid classes. All adjustments required to use CO-RE II stop disks are built into the new CO-RE II firmware.
Gravimetric Performance
g
TADM Performance
g
g Capacitive Liquid Level Detection (cLLD) g Filter Performance g Tip Pickup and Reliability g Chemical Compatibility g Lifetime Testing RISK MANAGEMENT Hamilton has assessed the risk of transitioning to CO-RE II tips and stop disks in detail. The following steps have been performed in order to mitigate risk:
Current CO-RE Tips
CO-RE II Tips Firmware Update Optional
Current CO-RE stop disk CO-RE II stop disk
Firmware Update Optional
Performance testing of CO-RE II tips with current CO-RE stop disks (backwards-compatibility) Testing of CO-RE II stop disks
g
Not Compatible
Firmware Update Mandatory
g
g Testing of supporting firmware, software, and hardware environment g Dedicated engineering and service resources will be available to support the transition g Maintaining the capability to produce current CO-RE tips at launch, but will be fully transitioning to CO-RE II production
Table 4: Firmware compatibilities.
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