Hamilton Automated Solutions Brochure

Empowering scientists to achieve more.

Automated Solutions Empowering Scientists to Achieve More

Over 50 Years of Experience in Automation

Content

EMPOWERING SCIENTISTS TO ACHIEVE MORE

For over 70 years, Hamilton has worked alongside those at the forefront of re- search. This exchange of knowledge allows Hamilton to transform the latest sci- entific trends into automated solutions – providing scientists with technology to accelerate their research. Today, Hamilton Robotics serves as a leading innovator in laboratory automation. The company introduced the world’s first semi-automated diluter in 1970 and the first fully automated workstation in 1980. The company continues to lead the in - dustry in groundbreaking robotic liquid-handling platforms, including the Microlab STAR line, introduced in the early 2000s. Additional platforms like the Microlab PREP, Microlab NIMBUS, and Microlab VANTAGE allow Hamilton to offer automated solutions for both simple and com- plex applications. The newest addition to the Hamilton line, Microlab STAR V, combines the flexibility of STAR with the high-end features of VANTAGE, improving speed and low-volume pipetting. The entire product portfolio offers maximum reliability, efficiency, flexibility, and user-friendliness. From production to service and support, the focus is always on your individual needs.

Automation Technologies

04 06

Platforms Entry Level Advanced Innovations MagPip VCMS Tools Temperature Keep Moving ID & Extraction

08 09 10 12 12 13 14 15 16 17

Consumables

Software

Sample Safety

Service & Support

Production

About

Contact

Unlock Your Lab's Full Potential

Looking for workstations that are assay ready?

Browse the Hamilton library of Assay Ready Workstations for your specific workflows, applications, or assay needs at: www.hamiltoncompany.com/arw

Hamilton instruments excel in automating multiple applications for both biological and analytical sciences. Thousands of STAR Line workstations have been installed around the world to automate a wide range of applications. They offer the flexibility and modularity users need to create the perfect automated solution for their laboratory. For specific demands, the Hamilton Application Engineering

and International support groups are available to design everything from custom racks to complex system integrations. We cover a wide range of applications, varying from genomics, cell biology, drug discovery applications to complex workflow solutions in biobanking. STAR Line- or VANTAGE Line-based automated applications vary from

simple benchtop solutions to complex, large-scale work- flows with automated sample management or different third-party device integrations. Hamilton offers pre-configured Assay Ready Workstations for a wide range of common applications. These include nucleic acid extraction, NGS library preparation, automat- ed PCR setup, blood fractionation, sample preparation,

and LC-MS. We can deliver a solution for nearly any routine laboratory workflow while providing the industry standard in customer service, user-friendliness, and pro- cess safety.

Technologies for Smart Automation

AUTOLOAD

CO-RE II – TIP/TOOL ATTACHMENT For the gentle GRIP

AEROSOL-FREE TIP EJECTION For the GENTLE TOUCH

CO-RE GRIPPER

For additional MOVEMENTS

For convenient IDENTIFICATION

The ability to move a plate to an incubation position can enable additional hands-free time. The CO-RE Gripper transforms pipet- ting channels into a simple plate gripper.

Attaching and releasing tips and tools with- out force avoids aerosol production.

CO-RE II technology enables force-less tip pick-up and eject, eliminating the risk of Aerosol production and possible contami- nation.

Eliminate manual errors with barcode- equipped Autoload and automatically detect and load deck equipment, while also scan- ning barcodes for complete sample tracking. Keep track of tip type and batch number with ease, ensuring accuracy in every step of your work.

DPS – DYNAMIC POSITIONING SYSTEM For efficient MOVEMENTS

DUAL LLD – DUAL LIQUID LEVEL DETECTION For smart ASPIRATIONS With conductive and pressure-based LLD, systems can detect the surface of any liquid. This ensures accuracy as liquids with high surface tension can “stick” to the outside of the tip, leading to high volume variations.

PLATE GRIPPER

MAGPIP

For OUTREACHERS

For CUTTING EDGE Liquid Handling

With a Plate Gripper, plates can be turned and fed to additional devices that extend the functionality of the system.

The tubular linear drive inside our MagPip channels can accelerate at speeds that enable low volume pipetting that are only known from dedicated systems.

DPS enables simultaneous pipetting of all channels even at irregular patterns, thus ensuring efficient liquid handling, unlike sys - tems with fixed channels.

MAD – MONITORED AIR DISPLACEMENT For unmatched RELIABILITY Monitored Air Displacement pipetting acts like a second set of eyes for all pipetting steps. It also ensures that the liquid has been aspirated correctly.

TADM – TOTAL ASPIRATION AND DISPENSE MONITORING

SCALABLE SYSTEM

For when TOMORROW comes

For inside INSIGHTS

Modern labs have to quickly adjust to changing requirements. Scalable Hamilton systems make it easy to increase capacity or add new functionalities.

TADM can detect even the smallest devia- tions from expected aspiration and dispense steps, ensuring results that you can trust.

Platforms Intro

Entry Level

AFFORDABLE ENTRY INTO THE WORLD OF AUTOMATION

FIND THE RIGHT HAMILTON PLATFORM FOR YOUR LAB

Microlab PREP – Big results, small package

Microlab NIMBUS – Efficiency in a small footprint

The Microlab PREP is designed to make research and experimentation convenient, efficient, and accurate. Com - pact and versatile, the platform allows users to maximize their workflows and achieve results they can count on. Easy setup means the PREP can go from unboxing to up and running in just 60 minutes. A small footprint allows the platform to easily fit on a benchtop or be stored when not in use. Operator-friendly software navigation allows users to program routine processes with the touch of a few buttons. Improve performance and increase productivity in your lab with the Microlab PREP!

Introduce your lab to the ultimate automation solution with Hamilton’s compact, multi-channel Microlab NIMBUS. Designed with speed, flexibility, ease of use, and superior pipetting performance in mind, NIMBUS is the perfect solution for any lab looking to improve efficiency and accu - racy. NIMBUS’s compact footprint allows it to easily fit in any lab, and its multi-channel capabilities allow it to handle multiple samples at once. Affordable and multifunctional, NIMBUS is a must-have for any laboratory.

Size (Width)

0.5 m

0.9 m

Hamilton’s automated liquid handling platforms are designed for exceptional performance. They feature cutting-edge innovations like CO-RE tech- nology and advanced monitoring tools like MAD and TADM. Additionally, Hamilton offers a wide range of accessories, devices, and consumables to customize your platform for maximum efficiency and walk-away time. Whether you’re looking to automate routine tasks, achieve reliable and consistent results, or stream- line your entire workflow, one of Hamilton’s five liquid handling platforms is the ideal solution for your lab’s needs.

Pipetting Option (max. Number)

1000 µL Channels (2)

1000 µL Channels (8)

Multi-Probe Head Option

96 or 384

Volume Range

1 µl - 1000 µl

1 µL - 1000 µL

Sample Tracking

with handheld Barcode Reader

Semi-Manual

Sample Loading

Manual

Device Integration

Hamilton Heater Shaker

On-deck or left side

Capacity (ANSI/SLAS Plates)

11, 12, or 20

Software

Microlab PREP Software

VENUS Software

Technologies

Advanced

Microlab STAR – Reliable liquid handling for 20 years (and counting)

STAR V – Boost productivity by 30%

Microlab VANTAGE Liquid Handling System– High-Throughput Automation Platform

The Microlab STAR is the workhorse of Hamilton’s au- tomated platform lineup, with over 20 years of proven performance and 20,000 satisfied customers. The STAR offers flexible customization, able to meet the needs of any application or requirement. Upgrade your laboratory with the STAR and see why it’s the gold standard in liquid automation.

The power of Hamilton’s VANTAGE meets the flexibility of STAR. Together, they create the Microlab STAR V, the future of lab automation. Streamline your laboratory’s workflows faster than ever before with a 30% increase in speed without sacrificing results. STAR V can easily inte - grate third-party devices from the back and side panels and also features a single multi-use arm that can handle every step along the process. Bring power and precision to your lab with the STAR V.

The VANTAGE Liquid Handling system is designed for the most demanding laboratory operations. It empowers automation experts to take control of their lab and opti- mize their workflow, with enhanced performance, 360° integration capabilities, and extended walk-away time for high-throughput labs. Whether you need to increase speed, accuracy, or efficiency, this system is tailored to meet the most demanding requirements.

Size (Width)

1.5 and 1.0 m

2.0 m and 1.3 m

Pipetting Option (max. Number)

1000 µL, 5 mL Channels (16, 8)

1000 µL, 5 mL, MagPip Channels (16, 8, 8)

Multi-Probe Head Option

96 or 384

96 and/or 384

Volume Range

1 µL - 5000 µL

0.35 µL - 5000 µL

Sample Tracking

with Autoload Barcode Scanner

Sample Loading

Automatic, Continuous

Automatic

Device Integration

180° (Left and Right)

270° (Left, Right, and Rear)

360° (Left, Right, Rear, and Below)

Capacity (ANSI/SLAS Plates)

45 or 25

60 or 35

60+

Software

new VENUS Software

Technologies

New Innovations MagPip

Vial Cap Management System

PIPETTING FROM THE FUTURE

AUTOMATE DE-CAPPING AND RE-CAPPING

We’re proud to be revolutionizing the world of pipetting with the new MagPip. There are thousands of reasons why this completely new technology represents the future. In short, it’s incredibly fast, covers a wide volume range, and is extremely precise. This leads to more efficiency across the entire workflow. Smaller volumes mean you’ll use fewer samples and reagents. The massive speed will increase throughput and save valuable time in the lab. The MagPip combines opposites – fast, while still being precise.

Hamilton’s Vial Cap Management System (VCMS) is a fully automated laboratory solution. VCMS eliminates repetitive tasks with the ability to vortex, de-cap, aliquot, and re-cap 96 vials in only 50 minutes. The system deliv - ers precise and accurate results while reducing the risk of human error, cross-contamination, and repetitive stress injuries.

VCMS streamlines productivity, easily detecting tube type, cap type, cap presence, and barcodes. Additionally, VCMS can easily integrate with Hamilton’s Microlab STAR to scan source and destination tubes.

Increase your lab’s efficiency and decrease costly mis - takes with Hamilton’s VCMS.

Speed of the MagPip Channels

Hamilton's MagPip channels utilize miniaturized compo- nents and a slim design to achieve unparalleled speeds. Linear motors on most axes generate smooth movement without the use of gears, spindles, or gear wheels.

Speed of the Tubular Linear Motor

MagPip’s air displacement pipetting uses a magnetized piston moved by the tube's magnetic field for unmatched acceleration.

Wide Range of Volumes and Liquid Classes

MagPip accelerates at a faster speed than conventional drives by fusing the pipetting piston in the tubular linear motor. As a result, the pipetting volume ranges from 350 nL to 750 μL.

Tools

Temperature

A SYSTEM AS INDIVIDUAL AS YOU ARE

All Hamilton systems are designed for change – offering increased flexibility and scalability. Modules can be added, removed, or rearranged quickly and easily, allowing for more adaptability to changing needs and environments. This modularity ensures that components are interchangeable and can be used with other components, making it easier to maintain, repair, and upgrade the system, giving users more control over how components interact, leading to more efficient and effective designs.

On-Deck Thermal Cycler (ODTC)

Sample Cooling Carrier

The ODTC is a fully automated on-deck thermal cycling solution. Designed for on-deck integration with all Ham- ilton liquid handling workstations, the on-deck footprint of the ODTC is equivalent to 2.5 ANSI/SLAS positions. Offering fast PCR runs and highest performance guaran- teed, the ODTC provides thermal cycling with INHECO’s innovative 3D vapor chamber technology (VCM ® ).

The Cooling Carrier Module combines two essential fea- tures: Keeping samples cooled to a predefined tempera - ture and enabling fully automated barcode identification via Autoload.

Works the Way You Do

Heating, Cooling, or Shaking

Hamilton Heater Shaker (HHS)

Hamilton Heater Cooler (HHC)

Select from individual Pipetting Channels with different volume ranges and Multi-Probe Heads that can simul- taneously pipette 96 and 384 samples. The interior of the selected pipetting system can be set up so that all sample and reagent vials can be handled safely, leading to results that you can trust.

With the addition of functional accessories, your system can perform almost anything: From simple shaking, cooling or heating to more demanding tasks like PCR, centrifugation or positive pressure chromatography – even fluorometric measurements. Everything is handled and easily controlled with VENUS software. When it comes to automating your assay, there are no limits.

The HHS automates the heating and shaking of ANSI/ SLAS footprint microplates. Multiple units may be integrat- ed and connected via a control box for higher throughput applications. Different adapters ensure optimal heat con- ductivity for all labware.

The HHC can heat plates up to 110 °C or keep samples cool at temperatures as low as 0 °C. It is compatible with NIMBUS, STAR, STAR V, and VANTAGE Platforms. It can also be used as a standalone benchtop device.

From a Simple Pipetting Platform to an Automated Workflow

Sometimes the ability to move a plate to an incubation position is all that is required to automate a whole new process. In addition to robotic Grippers that can transport and turn plates and even reach outside the instruments, all Hamilton platforms can simply pick up CO-RE Grippers with pipetting channels and move plates on- deck. Entry into more demanding automation workflows has never been easier and more affordable.

Hamilton Incubator Shaker (HIS)

The HIS provides fully automated incubation and shaking with on-deck loading and unloading functionality. Offering up to four independent incubation slots and full flexibility of ANSI/SLAS plate types, the HIS is completely controlled through VENUS software.

Keep Moving

I dentification & Extraction

On-Deck Centrifuge

Turn, Tilt, and Seesaw Modules

easyCode Carrier

[MPE] 2

The Hamilton Centrifuge is an ideal solution for on-deck centrifugation. The centrifuge is designed with two labware positions, accommodates labware up to 60 mm (maximum height), and reaches a maximum g-force of 2000 x g.

Whether plates have to be turned for incubation/reading positions, tilted to remove liquid from flat wells, or gently moved back and forth for incubation: There’s always the right MultiFlex Module to do exactly that.

Integration-friendly, the easyCode Carrier offers high performance 2D barcode reading right from the VENUS software’s interface. The proven vision and robotics technology ensures complete sample tracking for greater method security.

The [MPE] 2 is an all-in-one, compact device for auto- mating positive-pressure Solid Phase Extraction (SPE) and evaporation. Designed to easily integrate with all of Hamilton’s liquid handling platforms, easy installation and control via the VENUS software allows for upgrades to existing platforms.

Clear Vacuum Station

Active Plate Nest

Filtration-based purifications are easy with the single position, on-deck, automated vacuum station that is completely controlled through the VENUS software and consists of a manifold top, dedicated carrier, vacuum pump, and controller.

By temporarily fixing a plate in position, the Active Plate Nest prevents plates from lifting after piercing and pipet- ting and offers increased positional accuracy when pipet- ting 384- or 1536-well plates.

Consumables

BASIS OF EVERY WORKFLOW

Consumables are the essence of every workflow. That’s why Hamilton offers a wide range of high-quality consum- ables that provide security, efficiency, and convenience. Our tips are made in-house, guaranteeing the Hamilton standard of quality and availability. Tips are manufactured to the highest quality stan- dards Automated cleanroom production Automatic digital image processing inspections Complete, documented traceability Production areas in accordance with ISO-14644-1 (Class 8) Quality Management System in accordance with ISO 9001, ISO 13485, 21 CFR 820 (FDA Quality System Regulation) and EU In Vitro Diagnostics Directive Sterile CO-RE tips manufactured in accordance with ISO 11137-1, ISO 11137-2, and ISO 11137-3

New VENUS Software

KNOW ONE, KNOW ALL

OPERATE EVERYTHING FROM ONE CONTROL CENTER

Efficiency at Your Fingertips: The new VENUS

Intuitive Method Creation

Today’s automation solutions often require demanding integration of third-party equipment. Hamilton has responded to these needs with seamless integration via device drivers. Remote-controllable third-party components can be integrated into VENUS at any time, making your system integration friendly, flexible, and future-proof. Thanks to its open design, VENUS software can control most third-party hardware. Benefit from Hamilton’s outstanding error-handling concept, which provides multi-level error recoveries, even for non-Hamilton components. This intelligent setup guarantees worry-free operation in which all resources work seamlessly in one, integrated system.

Hamilton’s new VENUS software is designed to make lab automation user-friendly. VENUS is expanding from the Microlab STAR to the STAR V and VANTAGE, allowing you to transfer workflows between systems and platforms.

VENUS’s intuitive editors give you full control in every aspect of your method. It comes with guided steps for simple method creation and offers advanced program- ming functions for ultimate customization and flexibility. Customize your labware, dynamic pipetting patterns, individual volumes, error handling options, data handling, walk-away routines, and much more. For example, almost every programming step offers an individual treatment of every possible error case, in which automatic, semi-au- tomatic or manual recovery is selectable. It is an intuitive user interface to control the Microlab NIMBUS, Microlab STAR and STAR V, Microlab VANTAGE Line, and any third-party component that allows remote access. While programming, the intuitive and modular concept reduces programming time and lets you achieve results faster with less training. At runtime, intelligent dialogs (created with the Customized Dialog step) reduce error-prone user in - puts and provide clear visualization of method parameters or custom-tailored loading instructions.

VENUS Software

The system’s flexible hardware is reflected by the VENUS software, which provides several programming levels to fit your applications. VENUS offers simple-to-com - plex programming, without limiting your imagination or compromising your requirements. Additional software packages, such as the Dynamic Scheduler (for optimized resource use), the TADM feature (for full traceability of the pipetting workflow), the DatabasePlus option (to use remote tracking servers), and the Dynamic Liquid Classi - fication plugin (for automatic liquid class selection), make VENUS even more powerful.

Make it Yours

VENUS has a “Home” Screen that is completely custom- izable with your icons, photos, or images. This allows users to immediately identify their preferred methods and launch desired workflows by simply clicking on their personalized images.

New VENUS Software

Experience a seamless navigation experience with the all-new main interface of VENUS. The touchscreen-friendly cockpit view provides easy access to crucial information and functions at your fingertips. These include: Frequently used methods, Run History and status of the connect- ed system.

BETTER USER GUIDANCE AND PROGRAMMING

The VENUS software provides basic and advanced programming, offering flexible assay setup without compromising your requirements. Intuitive editors provide full control over every aspect of your method. VENUS is designed to be simple to use, yet powerful enough to provide the flexibility to set up assays exactly the way you want them automated.

Get organized and save time with the new Shortcuts menu. Create custom shortcuts to your fre- quently used methods, group them into folders, and personalize them with a variety of included icons and photos. You can even upload your own images to make it truly your own.

POWER STEPS

VENUS's Power Steps offer a quick and easy start into the world of automation, for everyone, at any time. There are six intuitive visual guides for the most frequently used pipetting tasks:

Streamline your workflow creation process with Power Steps in VENUS. Select from a variety of templates for common pipetting tasks, and easily customize spe- cific parameters such as volume and liquid type with the intuitive vi- sual guide. Simplify your work and save time with Power Steps.

Transfer Samples Add Reagents Serial Dilution Replicates Hit-Picking Load and Match

Safe Process

AUTOLOAD

THE SAMPLE IN FOCUS

INTELLIGENT PIPETTING

Hamilton understands how important process reliability is in the laboratory. That’s why we use a variety of sophisticated technologies and solutions to greatly reduce the po- tential for error. Know that your processes are secure with traceability throughout your workflow. Your lab’s procedures are in good hands with Hamilton!

WORKLIST HANDLING

Worklist Handling

2D BARCODE IDENTIFICATION

Badge Number Tracking

BADGE NUMBER TRACKING

SAMPLE

Autoload with Tracking

Customizable Error Recoveries

Labware Reporting

Intelligent Pipetting

Bi-Directional LIMS Integration

STATUS LIGHT

LIMS

Status Light

2D-Barcode Reading

PROCESS REPORT

Industry-Leading Support

SERVICE & SUPPORT YOU CAN COUNT ON Our worldwide Service organization strives to pro- vide the best service and support in the industry. Local engineers are trained by our Hamilton-cer- tified trainers and supported by Service centers and distributors. Our commitment to high-quality standards goes beyond ISO 9001 certification and

includes continuous training of all authorized ser- vice technicians. You can always rely on Hamilton for industry-leading service and support.

EXTRA-MILE SUPPORT

HIGHEST QUALITY LEVEL AND THE BEST SERVICE

Always there when you need us Our global field service and support network - from the technical support hotline to local service engi- neers and application specialists - guarantees a fast response to your request and minimizes downtime. Whether routine maintenance, service support, or ap - plication support, the Hamilton team ensures your lab will be back up and running as quickly as possible. Training makes perfect Hamilton offers customers in-depth training sessions to ensure laboratories know how to properly use their automated handlers. Whether a general overview of your equipment at a Hamilton facility or personalized sessions in your lab, we are committed to setting your team up for success.

Quality from a single source We guarantee the highest standards of quality, reliability, and precision for all our products, from our own production and state-of-the-art quality control systems to final inspection. System installation made to measure All Hamilton systems are installed according to strict procedures and in accordance with ISO 9001. Every system includes a comprehensive Installation Qualifi - cation (IQ) and detailed documentation. Service as individual as you are Ensure the longevity and peak performance of your automated system with a Hamilton service contract, including regular monitoring and preventative mainte- nance.

In-House Production

Top-quality products, all under one roof. Hamilton takes pride in its in-house production capabili - ties, allowing us to maintain high-quality standards and quickly adapt to an ever-changing market. In addition to developing our own software systems, Hamilton produces CNC parts and pipetting tips. Trust Hamilton to create the ultimate solution for your lab. HAMILTON UNDERSTANDS THE IMPORTANCE OF DEPENDABILITY. THAT’S WHY WE ARE COMMITTED TO PROVIDING OUR CUSTOMERS WITH THE PRODUCT SUPPORT THEY NEED. FROM IN-HOUSE PARTS TO CREATING CUSTOMIZED SOLUTIONS TAILORED TO MEET YOUR NEEDS, REST ASSURED YOU'RE IN GOOD HANDS WITH HAMILTON.

Automating Your Imagination

«We drive innovation to improve people's lives»

Hamilton Robotics

Hamilton Robotics is the industry leader in the development and production of state-of-the-art automated liquid handling systems and technologies. We drive innovation in laborato - ries around the world, turning concepts into realities. Our products are characterized by maximum reliability, effi - ciency, flexibility, and ease of use. From production to ser - vice to support, Hamilton’s focus is always on your individual needs.

Hamilton

Hamilton has been at the forefront of life science and med- ical technology for over 70 years. Our journey began as a visionary concept, transforming into a global company today. Though we’ve grown, Hamilton’s passion, curiosity, and in- novative spirit have never wavered. We remain committed to researching, developing, and producing cutting-edge solu- tions that improve people’s lives.

THE MEASURE OF EXCELLENCE

Germany, Austria, Switzerland +49 89 248 804 804

Denmark, Norway, Sweden, Finland +46 8410 27 373

France +33 184 008 420

Benelux +31 40 209 178 0

China +86 21 6164 6567

United Kingdom, Ireland +44 121 272 92 80

Japan +81 3 6435 6850

Spain, Portugal +34 930 186 262

Italy +39 039 930 06 06

United States +1-775-858-3000

Brazil +55 11 95914 5000

To find a subsidiary or distributor in your area, please visit www.hamiltoncompany.com/support.

United States +1-775-858-3000 United Kingdom, Ireland +44 121 272 92 80 Brazil +55 11 95914 5000 China +86 21 6164 6567

Denmark, Norway, Sweden, Finland +46 8410 27 373 France +33 184 008 420 Germany, Austria, Switzerland +49 89 248 804 804

Benelux +31 40 209 178 0 Italy +39 039 930 06 06 Japan +81 3 6435 6850 Spain, Portugal +34 930 186 262

Web: www.hamiltoncompany.com/robotics Email: infoservice@hamiltonrobotics.com

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