Microlab® Prep™ Welcome Packet

Unpack your Prep with these simple steps!

Nice to meet you Read me to get started.

Welcome to the Microlab Prep

Now that your Prep has arrived, you are only a few short steps away from easily automating your workflows.

Before you get started, check out HamiltonCompany.com/prephelp for the newest software version and other resources.

SECTION 1: REQUIREMENTS

First, decide on a space in your lab to put the Prep. Ensure your space fits the following specifications:

The space must have a level surface with enough room for the Prep:

Width: 21 in / 534 mm Depth: 25 in / 635 mm

Height, door closed: 24 in / 610 mm Height, door open: 32 in / 813 mm

Allocate additional space as needed so all parts of the Prep are easily accessible.

The area should be consistently well-lit, without shadows from windows (or other instruments) that would affect labware recognition.

The area must have an ambient temperature of 15–35°C (59–95°F) with a relative humidity of 15–85%, non-condensing.

The surface must be stable and able to support the Prep’s weight (91.5 lbs / 41.6 kg). Shaking and vibrations can negatively affect your results, especially for low-volume applications.

The space must have access to electrical power between 100 VAC to 240 VAC at 50 to 60 Hz.

Once you decide on a space, you can unbox and begin installing the Prep by following the instructions in this booklet.

SECTION 2: UNBOXING

Double-check both of the ShockWatches and TiltWatch on the outside of the box labeled “Accessories inside.” If either ShockWatch has a red tab, or if the balls in either TiltWatch sit at 40° or higher, contact Hamilton support. 1

30°

40°

50°

80°

60°

80°

60°

70°

100°

30°

40°

50°

80°

60°

70°

Remove the foam piece on top of the Prep. If the foam piece came off while lifting the box off the Prep, move on to step 3. Set aside all packing material to store later. If you need to repack your Prep for repair or return, you must use the same packing materials.

SECTION 2: UNBOXING

Remove the power cable from the top of the packaging and set it aside. 3

Un-tape and unfold the flaps of the bag. 4

SECTION 2: UNBOXING

Slide the next foam piece toward the front of the Prep, then lift it to remove it. 5

Remove the protective foam from the touchscreen. Move the flap on the plastic bag if needed. 6

SECTION 2: UNBOXING

Remove the protective foam from under the door by pulling upward and away from the Prep. 7

Roll the plastic bag down over the Prep. 8

SECTION 2: UNBOXING

Lift the Prep out of the lower box and place it on the bench. Make sure the location meets the requirements on page 4 for best results. The handles are located on the lower edge of the left, right, and back sides of the Prep; the foam base has cutouts for the handles. Do not lift or move the Prep with less than two people.

Open the door by pushing gently upwards on the bottom of the door. Remove the rubber band securing the waste bin to the waste block, then undo the twist-tie holding the waste bin down. Remove the black plastic waste bin and twist tie, which contains the Prep’s accessories.

Remove the plastic wrap and make sure the following are present:

■ Hex Wrench Set P/N 6603180-01

■ Liquid Waste Bottle P/N 6600264-01

■ CO-RE Paddles P/N 186105 (if the Prep has 2 Independent Channels)

■ Teaching Needle P/N 182176

■ Surface Level P/N 56659-01

■ Waste Bag Wire Stand P/N 6603149-01

■ Replacement Fuses P/N 1524-11

SECTION 2: UNBOXING

Remove the Velcro securing the support foam labeled “C,” then remove the support foam. 11

Remove the two red arm locks from the rail at the back of the Prep. Rotate the red key counter clockwise to remove, then pinch the clamp to detach. 12

SECTION 2: UNBOXING

Remove the thin foam strip labeled “B” at the back of the Prep. Pull the red tag up and to the right to remove it. 13

Move the pipetting arm to the right. Push gently on the front end of the arm to move it. 14

SECTION 2: UNBOXING

Remove the channel support foam (labeled “A”). 15

Peel the plastic wrap off of both outside panels and inside of the left side panel. 16

SECTION 3: PREPARING THE DECK

Remove the red channel locks from the pipetting arm, from front to back:

A. R otate key counter clockwise and remove it.

B. P inch the clamp and remove it.

C. Pull the channel to the front of the arm and repeat as necessary for each channel lock. ■ 2 Independent Channels: 3 locks ■ 8-Probe Head: 2 locks ■ 2 Independent Channels + 8-Probe Head: 4 locks

Move the pipetting arm back to the center. Push gently on the front end of the arm to move it. 18

SECTION 3: PREPARING THE DECK

Z-lock Removal instructions

A. L ocate Red channel locks. They are in back of each independent channel near the top of the instrument.

B. W hile holding the front of the channel with one

hand, Pull the lock toward the back of the instrument until it is removed. Repeat for both channels’ locks.

Install any devices you are integrating. Refer to the instructions included with your device. Continue to the next step if not applicable. 20

SECTION 3: PREPARING THE DECK

Install the deck: 21

A. R emove the deck and base plates from their packaging. If you have a device, the deck should have a cutout for it.

C. Install the base plates for each site. Press down on each plate to make sure it is secure.

B. P lace the deck frame on the Prep. The sites numbered 4 and 8 should be at the front.

4 8

Slide the waste bin into place, to the right of the waste block. 22

SECTION 4: GETTING STARTED

Place the liquid waste bottle in its place at the back of the waste bin. Make sure to remove the cap. 23

Place the steel teaching needle in its slot on the waste block. If your accessory kit has CO-RE paddles, place them on their

magnetic bracket on the back of the waste block.

SECTION 4: GETTING STARTED

Unwrap the cord set aside in Step 3 and connect the Prep to a power outlet. 25

Turn on the Prep and follow the instructions on-screen to begin setup. You will need a rack of tips for calibration during setup. To use 1,000 µL tips, make sure to remove the base plate from the site where they will be placed first. Removing the base plate is also required to use a tube pedestal or semi-skirted PCR plates.

SECTION 4: GETTING STARTED

If you have a barcode reader, connect it via USB after completing setup. The USB ports are on the left side of the Prep, near the bottom of the instrument.

You’re finished and ready to start PREP-ing!

SECTION 5: CONSUMABLES

Hamilton offers a wide range of consumables that work with the Microlab Prep depending on the needs for your workflow.

CO-RE II Tips — 50 µL

Available Options

Part Number Details

Case of 5,760 tips (Blister 5 x 96 tips per rack) Case of 5,760 tips (Blister 5 x 96 tips per rack) Case of 5,760 tips (Blister 5 x 96 tips per rack) Case of 5,760 tips (Blister 5 x 96 tips per rack)

50 μL Conductive Non-Sterile Filter Tip 235948

50 μL Conductive Non-Sterile Non-Filter Tips

235966

50 μL Conductive Sterile Filter Tips

235979

50 μL Conductive Sterile Non-Filter Tips

235978

50 μL Nested Conductive Non-Sterile Non-Filter Tips

Case of 11,520 tips (NTR 5 x 4 stack) Case of 11,520 tips (NTR 5 x 4 stack)

235947

50 μL Nested Conductive Sterile Non-Filter Tips

235987

CO-RE II Tips — 300 µL

Available Options

Part Number Details

Case of 5,760 tips (Blister 5 x 96 tips per rack) Case of 5,760 tips (Blister 5 x 96 tips per rack)

300 μL Conductive Non-Sterile Filter Tips 235903

300 μL Conductive Non-Sterile Non-Filter Tips

235902

To purchase consumables or look through our full product offering, visit HamiltonCompany.com/consumables .

CO-RE II Tips — 300 µL

Available Options

Part Number Details

Case of 5,760 tips (Blister 5 x 96 tips per rack) Case of 5,760 tips (Blister 5 x 96 tips per rack)

300 μL Conductive Sterile Filter Tips

235938

300 μL Conductive Sterile Non-Filter Tips 235937

300 μL Nested Conductive Non-Sterile Non-Filter Tips

Case of 11,520 tips (NTR 5 x 4 stack) Case of 11,520 tips (NTR 5 x 4 stack)

235950

300 μL Nested Conductive Sterile Non- Filter Tips

235985

CO-RE II Tips — 1,000 µL

Available Options

Part Number

Details

Case of 5760 tips (Blister 5 x 96 tips per rack) Case of 5760 tips (Blister 5 x 96 tips per rack) Case of 5760 tips (Blister 5 x 96 tips per rack) Case of 5760 tips (Blister 5 x 96 tips per rack)

1000 μL Conductive Non-Sterile Filter Tips 235905

1000 μL Conductive Non-Sterile Non-Filter Tips

235904

1000 μL Conductive Sterile Filter Tips

235940

1000 μL Conductive Sterile Non-Filter Tips 235939

SECTION 5: CONSUMABLES

Microlab Prep Accessories and Consumables

Available Options

Part Number

Details

24 position tube rack (Compatible tube size: 9.5–11.5 mm OD, 30–50mm H) 24 position tube rack (Compatible tube size: 10.5–16 mm OD, 75–125 mm H) 24 position tube rack for 15 mL conical tubes (14-16mm OD, 75-125mm H) and self-standing VTM-style tubes (14-16 mm OD, 75-105mm H)

24 Position Small Tube Rack

6600409-01

24 Position Large Tube Rack

6600555-01

15 mL Tube Rack

6605054-01

Framed Tip Rack

6600553-01

Rack for framed tips

Reagent Reservoir Rack

6600700-01

5 x 60 mL reagent rack

Handheld Barcode Scanner

6603432-01

1D handheld barcode scanner

Stand and cables for touch screen and enclosure removal

Fume Hood Kit

6603189-01

Heats up to 105 °C and Shakes up to 2500 rpm Heats up to 105 °C and Shakes up to 2500 rpm

3 mm Hamilton Heater Shaker

6601885-01

2 mm Hamilton Heater Shaker

6601885-02

Microlab Prep Accessories and Consumables

Available Options

Part Number

Details

Compatible magnetic plate for bead based extractions Compatible magnetic plate for bead based extractions Compatible magnetic plate for bead based extractions Compatible magnetic plate for bead based extractions Compatible magnetic plate for bead based extractions Adapter to improve cLLD performance for 384-well, full-skirt PCR plates

Invitrogen 96 Position Post Magnetic Plate 94696-01

Magnetic Well Ring Plate

OTP-TMOI-0051

Alpaqua Magnum FLX Magnetic Plate

OTP-ALPQ-0008

Alpaqua Magnum EX Magnetic Plate

OTP-ALPQ-0007

Alpaqua 96S Ring Magnetic Plate

OTP-A001322

cLLD Adapter 384-Well PCR Plates

6607478-01

Adapter to improve cLLD performance for 96-well, half-skirt PCR plate Adapter to improve cLLD performance for 96-well, full-skirt PCR plates

cLLD Adapter 96-Well, Half-Skirt PCR Plates

6607479-01

cLLD Adapter 96-Well, Full-Skirt PCR Plates

6607610-01

CO-RE I Stop Disk Removal Tool

6603034-01

Tool for replacing stop discs

SECTION 5: CONSUMABLES

Microlab Prep Accessories and Consumables Cont.

Available Options

Part Number

Details

CO-RE I Stop Disk Kit (2 channel)

Replacement stop disks, o-rings and washers Replacement stop disks, o-rings and washers 2-Pack replacement o-rings (CO-RE II only) 10-Pack replacement o-rings (CO-RE II only)

6603039-01

CO-RE I Multi Probe Head Stop Disk Kit (8 channel)

6603039-02

CO-RE II O-Ring Kit (2-Pack)

6607080-01

CO-RE II O-Ring Kit (10-Pack)

6607080-02

Lubrication for yearly maintenance

6603044-01

Silicone Oil

Photometric and gravimetric volume verification kit; includes two framed tip racks Photometric and gravimetric volume verification kit

Verification Kit with Two Framed Tip Racks 6604125-01

Verification Kit (Liquids and Labware)

6604125-02

Biohazard Waste Bags

6603183-01

Tip waste bags (50 per roll)

SECTION 6: SUPPORT

Hamilton is here for you! Browse our online help center for troubleshooting information, file a support ticket, and download the latest software updates. Visit HamiltonCompany.com/prephelp .

©2023 Hamilton Company. All rights reserved. All other trademarks are owned and/or registered by Hamilton Company in the U.S. and/or other countries. Lit. No. BR-2305-22 v3.0 — 08/2023 P/N 6603239-01_B

United States +1-775-858-3000 United Kingdom, Ireland +44 (0) 121 272 92 80 Brazil +55 (11) 126 50562 China +86 21 6164 6567 France +33 184 008 420 Italy +39 39 689 33 93

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To find a subsidiary or distributor in your area, please visit, www.hamiltoncompany.com/contacts.

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